منابع مشابه
Hypertriglyceridemia in Gout.
THE incidence of arteriosclerosis is reported to be greater in patients with gout than in control groups. In one study of 280 individuals with gout, 39 per cent had clinical or electrocardiographic evidence -of cardiovascular disease and 45 per cent had hypertension.' Severe involvement of the coronary or cerebral vessels and marked renal arteriosclerosis are major factors in producing death in...
متن کاملHypertriglyceridemia
Hypertriglyceridemia (HTG) is commonly encountered in lipid and cardiology clinics. Severe HTG warrants treatment because of the associated increased risk of acute pancreatitis. However, the need to treat, and the correct treatment approach for patients with mild to moderate HTG are issues for ongoing evaluation. In the past, it was felt that triglyceride does not directly contribute to develop...
متن کاملGout. Mechanisms of inflammation in gout
An acute attack of gout is a paradigm of acute sterile inflammation, as opposed to pyogenic inflammation. Recent studies suggest that the triggering of IL-1beta release from leucocytes lies at the heart of a cascade of processes that involves multiple cytokines and mediators. The NLRP3 inflammasome appears to have a specific role in this regard, but the biochemical events leading to its activat...
متن کاملGout. Epidemiology of gout
Gout is the most prevalent form of inflammatory arthropathy. Several studies suggest that its prevalence and incidence have risen in recent decades. Numerous risk factors for the development of gout have been established, including hyperuricaemia, genetic factors, dietary factors, alcohol consumption, metabolic syndrome, hypertension, obesity, diuretic use and chronic renal disease. Osteoarthri...
متن کاملHypertriglyceridemia in Transgenic Mice
We have generated transgenic mice expressing the human apolipoprotein CII (apoCI ) gene under the transcriptional control of the human cytochrome P450 IA1 (CYPIAl) promoter. Human apoCIt transgenic (HuCIITg) mice exhibited significant basal expression of the transgene (plasma apoCIl level = 26.1±4 mg/dl) and showed further induction of transgene expression after treatment with fl-naphthoflavone...
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ژورنال
عنوان ژورنال: Circulation
سال: 1964
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.29.4.508